Table 1.
Review of cases of pulmonary nocardiosis by N brasiliensis reported from India
| Author/Year | Age (years)/Sex | Predisposing or underlying condition | Clinical presentation | Radiological features | Specimen | Anti-biotic therapy | Outcome | Drug Susceptibility Testing |
|---|---|---|---|---|---|---|---|---|
| Wadhwa V et al.[4] 2006 | 42/M | COPD, chronic steroid therapy | Cough, dyspnea, fever for 5 days | CXR: B/L infiltrates and patchy consolidation | Sputum | CTR, AMK, CTZ | Died | S- AMG, CMP. R- COT, ERY, CTR, AMP, CFX. |
| Shivaprakash MR et al.[5] 2007 | 40/M | Post renal transplant, DM | Right eyelid swelling*, cough, sputum, hemiparesis | CXR: B/L infiltrates; MRI brain: multiple RELs | Pus, BAL, sputum | COT, AMX | Died | S- COT, AMK, CFT, IMP. |
| Shivaprakash MR et al.[5] 2007 | 45/M | Type 2 DM, steroid therapy | Cough, sputum, dyspnea | CT: consolidation with areas of breakdown and air fluid level | BAL | COT, CFP | Improved | S- COT, AMK, CFT, IMP. |
| Chawla K et al.[6] 2009 | 52/M | BA, steroid therapy | Dyspnea for 10 days | Pleural effusion | Pleural fluid | COT | Improved | S- COT. |
| Amatya R et al.[7] 2011 | 26/F | Pregnancy | Cough, dyspnea, right hand swelling and right axillary sinus* for 1 year | CXR: Opacities in left hemithorax and right upper lobe | Sputum, pus and tissue from swelling | COT | Improved | NA |
| Rawat et al.[8] 2011 | 65/M | COPD | Cough, sputum, fever for 2 months | CXR: right apex consolidation and right lower lobe cavity | Sputum | AMK, CFT | Improved | S- COT, AMG, CMP, TC. R- AMX, AMP, PIP, ERY, CFX. |
| Khare V et al.[9] 2013 | 85/F | COPD, chronic steroid therapy | Fever, cough, dyspnea for 10 days | CXR: patchy infiltrates in right lung and left hemithorax consolidation | Sputum, endotracheal aspirate | CTR, LFX, COT | Died | S- IMP, AMG. R- COT, ERY, CFX. |
| Bagali S et al.[10] 2016 | 45/M | Rheumatic heart disease | Cough, sputum, hemoptysis, dyspnea for 1 month | CXR: right pleural effusion and cardiomegaly | Pleural fluid | PIP | Died | NA |
| Index case | 65/M | COPD, previously treated PTB | Fever, cough, dyspnea for 7 days | CXR: B/L air space opacities with right upper lobe fibrosis | Sputum | CTR, AMK, OFX, COT | Died | S- AMK, CTR, TC, CMP, IMP. R- COT, AZT. |
*Primary cutaneous nocardiosis Abbreviation: B/L=bilateral, CTR=ceftriaxon, AMK=amikacin, CTZ=ceftazidime, AMG=aminoglycosides, CMP=chlorampenicol, COT=cotrimoxazole, ERY=erythromycin, CTR=ceftriaxone, AMP=ampicillin, CFX=ciprofloxacin, AMX=amoxicillin, CFT=cefotaxim, IMP=imipenem, CT=computed tomography, CFP=cefepime, TC=tetracycline, PIP=piperacillin, LFX=levofloxacin, OFL=oflaxacin, AZT=aztreonam, NA=data not available