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. 2019 Oct 23;10:2484. doi: 10.3389/fimmu.2019.02484

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Copyright © 2019 Mohammed, Khan, Chatzistamou, Chamseddine, Williams-Kang, Perry, Enos, Murphy, Gomez, Aladhami, Oskeritzian, Jolly, Chang, He, Pan and Kubinak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Malabsorption in CD19^−/− mice is gluten-sensitive. (A) Total serum IgG and IgA and total AGA antibody titers are shown. (B) Correlation between AGA antibody titers and total IgG/IgA titers in WT and CD19^−/− mice. (C) Malabsorption scoring for GFD-treated CD19^−/− mice compared to animals reared on a gluten-containing mouse chow. (D) Representative anti-CD3 IHC staining of ileal T cells in CD19^−/− mice treated with GFD vs. controls. (A) Student's t-test, **** = p < 0.0001. (C) Result of Two-way ANOVA (row factor = genotype), **** = p < 0.0001.