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. Author manuscript; available in PMC: 2019 Oct 30.
Published in final edited form as: Chem Phys Lipids. 2019 Jan 29;219:28–35. doi: 10.1016/j.chemphyslip.2019.01.009

Table 1. Hypochlorite chlorinates multiple tyrosine residues in apoA-I.

ApoA-I was treated with hypochlorite (149μM) and resolved on an SDS gel. The band was excised and subjected to tryptic digestion. Mass spectrometry analysis revealed the presence of chlorinated tyrosine (Y) residues in six tryptic fragments of apoA-I.

Peptide Fragment Modification Residue m/z Ratio Charge State
DLATVYVDVLK Chlorinated Y18 635.328 2+
DYVSQFEGSALGK Chlorinated Y29 717.820 2+
VQPYLDDFQK Chlorinated Y100 643.796 2+
THLAPYSDELR Chlorinated Y166 445.876 3+
THLAPYSDELR Dichlorinated Y166 457.195 3+
VSFLSALEEYTK Chlorinated Y236 710.842 2+