Table 1.
Patient | Sex | Age, yr | M Protein |
Previous Chemotherapy | Disease Status at SCT |
Risk Status |
BATs Dose, 109 |
Stem Cell Dose, 106/kg |
Current Disease Status |
Days to Engraftment |
TTP Post- SCT, mo |
Survival Post-SCT, mo |
Maintenance Therapy |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | F | 66 | IgG | (B + D) × 2 | VGPR | Int | 24 | 6 | REL | 11 | 6.4 | 26.7* | Revlimid |
2 | M | 41 | IgG | (L + D) × 4 | CR | ND | 30 | 7.58 | uCR | 13 | 69.30 | Revlimid | |
3 | F | 54 | IgA | (B, dox, D) × 6 | PR | High | 20 | 10.26 | REL | 17 | 26.2 | 66.93 | Revlimid |
4 | F | 49 | IgG | (B, ex, L) × 3 | PR | High | 20 | 14 | REL->SD | 23 | 3.3 | 64.90 | Revlimid |
5 | M | 59 | IgA | (L + D) × 4 | CR | Low | 20 | 7.89 | **REL-alloBMT | 17 | 15.8 | 63.67 | Revlimid |
6 | F | 40 | IgA | (B + dox, D) × 3 | VGPR | High | 30 | 7.17 | REL | 13 | 42.4 | 63.97 | Revlimid |
7 | M | 66 | IgG | (B + D) × 6 | PR | ND | 20 | 20.87 | uCR | 21 | 62.73 | Revlimid | |
8 | F | 66 | IgG | (B+ TI + D × 3 | PR | ND | 20 | 8.18 | uCR | 12 | 62.57 | Revlimid | |
9 | F | 66 | IgG | (B + D) × 4 | PR | ND | 20 | 7.96 | uCR | 18 | 62.50 | Revlimid | |
10 | M | 62 | IgA | (B + D) × 8 | VGPR | Low | 20 | 11.7 | REL | 16 | 14.8 | 57.67 | No maintenance |
11 | M | 57 | IgG | (B + D) × 3 | VGPR | Low | 30 | 7.56 | REL | 18 | 22.3 | 56.90 | No maintenance |
12 | M | 53 | Non-S | (T, B + D + T, B + D) | CR | Low | 30 | 5.05 | uCR | 14 | 56.50 | No maintenance | |
Median | 58 | 15.8 | 62.6 |
B indicates bortezomib; VGPR, very good partial remission; Int, intermediate risk; L, lenalidomide; D, dexamethasone; CR, complete remission based on bone marrow biopsy; ND, not determined owing to the lack of cytogenetics at the time of diagnosis; uCR, complete remission based on lack of serum MM protein detected because bone marrow biospies were not part of the standard of care at the institution; dox, doxorubicin; PR, partial remission; BMT, bone marrow transplantation; T, thalidomide; Non-S, nonsecretory.
Bold text indicate the patients who received booster infusions.
Patient expired from progressive disease.
Underwent allogeneic SCT while in PR.