Table 3.
Results of the baseline rs-FC contrast (FM vs HC).
| Seed | Correlated Area | MNI Coordinates | β | T | p-FDR | Connectivity |
|---|---|---|---|---|---|---|
| Pain Matrix* | L PCN | −02, −60, 26 | 0.23 | 4.4 | <0.001 | Higher |
| L SFG | −20, 40, 40 | 0.22 | 5.8 | <0.001 | Higher | |
| R MidFG | 26, 26, 36 | 0.23 | 5.4 | 0.001 | Higher | |
| R PaCiG | 04, 52, 08 | 0.23 | 4.7 | 0.009 | Higher | |
| L PCC | −06, −50, 18 | 0.22 | 4.6 | 0.05 | Higher | |
| R INS | 36, −20, −10 | −0.21 | −6.7 | 0.03 | Lower | |
| R ACC | R SI | 60, −04, 36 | −0.24 | −5.2 | 0.006 | Lower |
| L ACC | R STG | 68, −16, 04 | −0.22 | −7.0 | 0.01 | Higher |
| L AMYG | L CRBL | −26, −76, −30 | −0.22 | −5.7 | 0.04 | Lower |
| L AnG | R PCN | 06, −64, 40 | 0.31 | 6.2 | <0.001 | Higher |
| L PaCiG | −04, 54, 18 | 0.29 | 7.5 | <0.001 | Higher | |
| R TP | 58, −02, −26 | 0.28 | 7.4 | <0.001 | Higher | |
| L MTG | −56, −04, −26 | 0.31 | 6.4 | <0.001 | Higher | |
| L SubCalC | −06, 16, −20 | 0.25 | 6.4 | <0.001 | Higher | |
| L FP | −12, 40, 44 | 0.32 | 5.0 | 0.02 | Higher | |
| R CRBL | 10, −44, −48 | 0.23 | 6.1 | 0.02 | Higher | |
| L INS | −30, 20, 10 | −0.26 | −7.6 | 0.02 | Lower | |
| R SMG | 64, −28, 26 | −0.24 | −4.6 | 0.02 | Lower | |
| L MidFG | −46, 32, 26 | −0.28 | −4.7 | 0.02 | Lower | |
| R INS | 34, 20, 04 | −0.24 | −4.6 | 0.05 | Lower | |
| R GP | L IFG | −52, 16, 24 | 0.20 | 5.6 | 0.03 | Higher |
| L GP | L SMG | −58, −40, 52 | 0.21 | 5.4 | 0.005 | Higher |
| R SMA | 00, 02, 46 | 0.18 | 5.6 | 0.05 | Higher | |
| R SPL | 28, −46, 54 | 0.19 | 5.3 | 0.05 | Higher | |
| L FP | −10, 44, 02 | −0.22 | −5.1 | <0.001 | Lower | |
| L PCN | −12, −60, 16 | −0.19 | −4.4 | 0.05 | Lower | |
| L INS | L PCN | −18, −58, 16 | −0.22 | −6.1 | 0.01 | Lower |
| L mPFC | L AnG | −44, −58, 52 | 0.25 | 4.9 | 0.004 | Higher |
| R FP | 20, 56, −06 | 0.29 | 5.4 | 0.01 | Higher | |
| R PCC | R PaCiG | 02, 42, 26 | 0.26 | 5.9 | <0.001 | Higher |
| L PCC | 00, −38, 44 | 0.24 | 5.4 | 0.005 | Higher | |
| R FP | 42, 56, 14 | 0.22 | 7.1 | 0.02 | Higher | |
| L AnG | −50, −60, 28 | 0.27 | 4.5 | 0.05 | Higher | |
| L PCC | R PCN | 10, −56, 28 | 0.30 | 6.7 | <0.001 | Higher |
| L SLOC | −40, −72, 32 | 0.30 | 6.8 | <0.001 | Higher | |
| R PaCiG | 02, 44, 26 | 0.25 | 6.9 | <0.001 | Higher | |
| R SLOC | 44, −54, 28 | 0.27 | 6.3 | <0.001 | Higher | |
| R SMA | L SMA | −04, −16, 64 | −0.29 | −7.5 | <0.001 | Lower |
| R TP | 56, 16, −06 | −0.27 | −6.5 | <0.001 | Lower | |
| R M1 | 54, 00, 44 | −0.24 | −6.3 | 0.002 | Lower | |
| L TP | −54, 18, −10 | −0.23 | −5.4 | 0.02 | Lower | |
| L THA | L PaCiG | −08, 34, 26 | 0.22 | 5.6 | 0.01 | Higher |
| PAG | 00, −38, −48 | 0.19 | 6.0 | 0.02 | Higher |
FM, fibromyalgia patients; HC, healthy controls; BL, baseline condition; rs-FC, resting-state functional connectivity; β, effect size (positive effects represent higher connectivity; negative effects represent lower connectivity); T, T-value; p-FDR, p corrected false discovery rate; L, left; R, right. Significant seeds: Pain matrix (*34 seeds merged in an a priori mask); ACC, anterior cingulate cortex; AMYG, amygdala; AnG, angular gyrus; GP, globus pallidus; GP, globus pallidus; INS, insular cortex; mPFC, medial pre-frontal cortex; PCC, posterior cingulate cortex; PCC, posterior cingulate cortex; SMA, supplementary motor area; THA, thalamus. Correlated areas: AnG, angular gyrus; CRBL, cerebellum; FP, frontal pole; IFG, inferior frontal gyrus; INS, insular cortex; SLOC, superior lateral occipital cortex; MTG, medial temporal gyrus; MidFG, middle frontal gyrus; PaCiG, paracingular gyrus; PAG, periaqueductal gray matter; M1, precentral gyrus (primary motor cortex); SI, postcentral gyrus (primary somatosensory cortex); PCN, precuneus; PCC, posterior cingulate cortex; SubCalC, subcallosal cortex; SMG, supramarginal gyrus; SFG, superior frontal gyrus; SPL, superior parietal lobe; SMA, supplementary motor area; STG, superior temporal gyrus; TP, temporal pole. All analyzed contrasts were corrected for multiple comparisons using the false discovery rate (FDR) at 0.05.