Table 4.
Resting state functional connectivity of music-induced analgesia. Main effects and interaction.
| Seed | Correlated Area | MNI Coordinates | β | p-FDR | Connectivity |
|---|---|---|---|---|---|
| Group main effect (FM vs HC): [F(8,152) = 4.47, p = < 0.001] | |||||
| Pain matrix* | R PCN | 02, −62, 34 | 0.30 | <0.001 | Higher |
| L PCN | −04, −68, 28 | 0.35 | 0.004 | Higher | |
| L INS | −30, 14, 02 | 0.32 | 0.004 | Higher | |
| L PCC | −06, −54, 08 | 0.28 | 0.007 | Higher | |
| R AnG | 36, −68, 54 | 0.18 | 0.04 | Higher | |
| Condition main effect (Music vs Pink noise): [F(8,152) = 8.33, p = 0.02] | |||||
| Pain matrix* | R ACC | 02, 06, 42 | 0.35 | 0.02 | Higher |
| Time main effect (Pre- vs Post-test): [F(8,152) = 4.1, p = 0.02] | |||||
| Pain matrix* | R PaCiG | 02, 48, 16 | −0.17 | 0.02 | Lower |
| R AnG | 30, −68, 34 | 0.19 | 0.02 | Higher | |
| R MidFG | 48, 24, 28 | 0.21 | 0.02 | Higher | |
| R PCN | 06, −76, 38 | 0.15 | 0.02 | Lower | |
| 3-way interaction (Group × Condition × Time): [F(8,152) = 3.24, p = <0.001] | |||||
| Pain matrix* | R PCN | 02, −72, 34 | 0.30 | <0.001 | Higher |
FM, fibromyalgia patients; HC, healthy controls; Mpre, pre-music; Mpos, post-music; β, effect size; p-FDR, p corrected false discovery rate; L, left; R, right. Significant seed: Pain matrix (*12 seeds that resulted from BL analysis, merged in a post hoc mask). Correlated areas: ACC, anterior cingulate cortex; AnG, angular gyrus; INS, insula; MidFG, middle frontal gyrus; PaCiG, paracingulate gyrus; PCN, precuneus; PCC, posterior cingulate cortex. All analyses were corrected for multiple comparisons using the false discovery rate (FDR) at 0.05.