Table 5.
Post hoc paired t-test for Mpre vs Mpos rs-FC contrast analysis in FM patients and HC.
| Seed | Correlated Area | MNI Coordinates | β | T | p-FDR | Connectivity |
|---|---|---|---|---|---|---|
| Fibromyalgia patients | ||||||
| Pain matrix* | R PCN | 01, −40, 46 | −0.18 | −6.2 | 0.02 | Decreased |
| R PCC | 02, −18, 32 | −0.17 | −6.1 | 0.05 | Decreased | |
| R OFC | 48, 22, −14 | −0.19 | −7.6 | 0.02 | Decreased | |
| L ACC | R STG | 68, −16, 04 | −0.22 | −7.1 | <0.001 | Decreased |
| R SPL | 18, −52, 72 | −0.21 | −6.2 | 0.04 | Decreased | |
| L AMYG | R MidFG | 28, 30, 36 | 0.18 | 6.0 | 0.02 | Increased |
| L AnG | R SFG | 10, 16, 64 | −0.22 | −6.2 | 0.01 | Decreased |
| L SFG | −08, 18, 60 | −0.22 | −7.6 | 0.03 | Decreased | |
| R PCC | 02, −16, 48 | −0.21 | −7.1 | 0.05 | Decreased | |
| R MTG | 70, −16, −08 | −0.25 | −8.0 | 0.05 | Decreased | |
| R PCN | 10, −56, 28 | −0.21 | −7.0 | 0.05 | Decreased | |
| L INS | L M1 | −18, −26, 56 | −0.18 | −8.7 | 0.03 | Decreased |
| Healthy controls | ||||||
| Pain matrix* | L SLOC | −48, −50, 40 | 0.20 | 4.5 | 0.03 | Increased |
| R AMYG | R SI | 56, −14, 32 | 0.17 | 5.4 | 0.02 | Increased |
| L SLOC | −20, −74, 34 | 0.18 | 7.1 | 0.03 | Increased | |
| R SLOC | 16, −80, 44 | 0.20 | 5.0 | 0.04 | Increased | |
| R AnG | L LG | −14, −56, −02 | 0.19 | 5.9 | 0.03 | Increased |
| R INS | L CRBL | −38, −86, −24 | −0.18 | −6.4 | 0.03 | Decreased |
FM, fibromyalgia patients; HC, healthy controls; Mpre, pre-music; Mpos, post-music; rs-FC, resting-state functional connectivity; β, effect size; T, T-value; p-FDR, p corrected false discovery rate; L, left; R, right. Significant seeds: Pain matrix (*12 seeds that resulted from BL analysis, merged in a post hoc mask); ACC, anterior cingulate cortex; AMYG, amygdala; AnG, angular gyrus; INS, insular cortex. Correlated areas: CRBL, cerebellum; LG, lingual gyrus; MidFG, middle frontal gyrus; MTG, middle temporal gyrus; M1, precentral gyrus (primary motor cortex); OFC, orbitofrontal cortex; PCN, precuneus; PCC, posterior cingulate cortex; SI, postcentral gyrus (primary somatosensory cortex); SFG, superior frontal gyrus; SLOC, superior lateral occipital cortex; SPL superior parietal lobe; STG superior temporal gyrus. All analyzed contrasts were corrected for multiple comparisons using the false discovery rate (FDR) at 0.05.