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. 2019 Oct 29;9:15471. doi: 10.1038/s41598-019-51881-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Therapy study in s.c. xenograft-bearing mice using nanoparticle-formulated siRNAs. (A) Tumor growth curves of Colo357 xenografts upon treatment with PEI-complexed specific or non-specific siRNAs. Right panel: representative examples of mice upon termination of the experiment. (B) Quantitation of NRP2 (left) or NRP1 protein levels (right) in tumor xenografts after explantation. Lower panel: representative Western blots of tumor lysates from tumor xenografts treated as indicated. (C–H) Immunohistochemistry of transplanted tumors, stained with antibodies against the silenced proteins. Representative tissue pieces of tumor xenografts from mice treated with specific siRNA (right panels) vs. negative control treatments (left panels) are shown. Tissues are stained for NRP1 (C,D), NRP2 (E,F) and GIPC1 (G,H). Bar: 2 µm. (I–K) Graphs illustrating the quantitation of immunoreactive staining. Means of the immunoreactive score of the specific staining is given for all treatment groups, with tissues stained for NRP1 (I), NRP2 (J) and GIPC1 (K).