Table 1.

Rotarod and OFT behavioral Testing.

	2 hours Post					24 hours Post
	Sham		HIFU		P value	Sham		HIFU		P value
	Mean ± SE	CV	Mean ± SE	CV		Mean ± SE	CV	Mean ± SE	CV
Rotarod (Motor Cortex) (s) (n = 8)	135.50 ± 13.09	0.2732	43.25 ± 13.37	0.8744	0.0003	129.28 ± 16.60	0.3631	23.38 ± 3.86	0.4673	<0.0001
Rotarod (Frontal Cortex) (s) (n = 6)	140.60 ± 14.90	0.2596	34.73 ± 11.94	0.8423	<0.0001	149.27 ± 9.15	0.1502	28.77 ± 7.05	0.6006	<0.0001
OFT: Distance Travelled (m) (n = 8)	34.52 ± 0.82	0.0670	21.70 ± 2.69	0.3505	<0.0001	21.10 ± 1.68	0.2249	16.05 ± 1.85	0.1150	0.1053
OFT: Time in the Center (s) (n = 8)	45.99 ± 7.78	0.4795	72.14 ± 20.58	0.8067	0.1685	11.84 ± 2.53	0.6049	28.11 ± 8.33	0.8384	0.6053
OFT: Freezing Time (s) (n = 8)	18 ± 2.84	0.4464	76.13 ± 22.24	0.8265	0.0249	71.88 ± 13.09	0.5149	113.50 ± 19.35	0.4821	0.1741
	1 week Post					1 month Post
	Sham		HIFU		P value	Sham		HIFU		P value
	Mean ± SE	CV	Mean ± SE	CV		Mean ± SE	CV	Mean ± SE	CV
Rotarod (Motor Cortex) (s) (n = 8)	87.08 ± 22.88	0.7432	23.98 ± 7.26	0.8560	0.0205	72.58 ± 26.00	1.0131	12.40 ± 3.62	0.8247	0.0426
Rotarod (Frontal Cortex) (s) (n = 6)	133.37 ± 24.57	0.4514	42.52 ± 12.12	0.6985	0.0002	119.93 ± 17.74	0.3624	35.70 ± 7.65	0.5249	0.0006
OFT: Distance Travelled (m) (n = 8)	21.37 ± 1.48	0.1970	17.06 ± 1.41	0.0829	0.2129	19.99 ± 0.87	0.1244	16.77 ± 0.89	0.1500	0.4876
OFT: Time in the Center (s) (n = 8)	11.90 ± 0.94	0.2222	22.68 ± 6.41	0.7994	0.8722	16.05 ± 5.08	0.8942	19.89 ± 4.84	0.6888	0.9969
OFT: Freezing Time (s) (n = 8)	73.75 ± 10.12	0.3879	108.75 ± 17.74	0.4614	0.3226	83.38 ± 11.35	0.3850	112.75 ± 9.01	0.2260	0.4944

(Two-way mixed-effects model followed by Sidak’s multiple comparison test [GraphPad Prism]).