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. 2019 Oct 29;10:4777. doi: 10.1038/s41467-019-11984-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Demonstration of time-dependent mapping of collagen heterogeneity in DEN model. a T1-, T2-weighted, and T1-inversion recovery images of DEN-induced diseased liver before and 3 and 24 h post injection of ProCA32.collagen1 demonstrating collagen heterogeneity of liver in Area 2 (A2). b Sirius red staining and CPA analysis confirmed that A2 has more collagen than A1 which correlates with MRI (scale bar, 100 µm). c T1-, T2-weighted, and T1-inversion recovery images all demonstrated a higher contrast to noise ratio (CNR) in A2 of liver 3 h after ProCA32.collagen1 injection compared to A1. Data are represented as mean ± SD, n = 4 independent images. d Percentage of relative enhancement and quantitative voxel analysis of T1-inversion recovery images demonstrating liver regions enhanced at 3 and 24 h after injection of ProCA32.collagen1 compared to pre-injection (color scale represents number of voxels). e Percentage of relative enhancement and quantitative voxel analysis of T2-weighted images of liver demonstrating regions enhanced at 3 and 24 h after injection of ProCA32.collagen1 compared to pre-injection (color scale represents number of voxels)