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. 2019 Oct 29;10:4777. doi: 10.1038/s41467-019-11984-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Human translational potential of ProCA32.collagen1. a ProCA32.collagen1 enhanced MRI can demonstrate different collagen distribution in DEN-, NASH diet-, and TAA/alcohol-induced models. b Schematic illustration of ProCA32.collagen1 distribution and suggested mechanism in different stages of fibrosis. c Demonstration of three hepatocellular carcinoma (HCC) and normal human liver tissue microarray stained with Sirius red (red) and ProCA32.collagen1 (brown) exhibiting the strong binding of the contrast agent to collagen human patient tissue (all scale bars, 100 µm)