Table 1.
Summary of r1 and r2 relaxivity of ProCA32.collagen1 and non-PEGylated ProCA32.collagen1 and their comparison with ProCA32 and clinical contrast agents at 1.4 and 7.0 T, 37 °C
| Contrast agent29,30 | r1 at 1.4 T | r1 at 7.0 T | r2 at 1.4 T | r2 at 7.0 T |
|---|---|---|---|---|
| Magnevist (Gd-DTPA) | 3.3 | 5.1 | 3.9 | 9.4 ± 1.3 |
| Eovist (EOB-DTPA) | 5.38 ± 0.02 | 5.37 | 6.54 ± 0.06 | 7.01 |
| Dotarem (DOTA) | 3.9 ± 0.2 | N/A | 3.2 ± 0.7 | N/A |
| MultiHance (BOPTA) | 6.20 | N/A | 8.7 | N/A |
| ProHance (HP-DO3A) | 4.39 | N/A | 5.0 | N/A |
| ProCA32 | 33.14 ± 0.32 | 18.9 | 44.61 ± 0.12 | 48.6 ± 0.1 |
| Non-PEGylated ProCA32.collagen1 | 30 ± 0.06 | N/A | 42 ± 0.1 | N/A |
| ProCA32.collagen1 | 34 ± 0.12 | 21.3 ± 0.5 | 50 ± 0.16 | 108.5 ± 1.2 |
r1 and r2 values are reported per Gd3+