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. 2019 Oct 29;9:15560. doi: 10.1038/s41598-019-52146-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Long-term protective efficacy against the hypervirulent Mtb K strain using a prime/boost regimen with BCG and the ID93/GLA-SE vaccine candidate. (A) CFUs in the lungs and spleens of each group at 16 weeks post infection was analysed by enumerating the viable bacteria. (B) The superior lobes of the right lung of each immunised mouse were analysed using H&E staining (3B, upper left and bottom), and representative lung lobes were depicted as gross images (3B, upper right) at 16 weeks after Mtb K infection (1X: Scale bar = 2.0 mm, 10X: Scale bar = 0.5 mm). (C) The experimental results indicate the percentage of inflamed area and the size of lesions in the lung, and are described through box and whisker plots. Data from each immunised group (n = 8) at designated time point are described. One-way ANOVA followed by Tukey’s multiple comparison test was used to evaluate the significance. n.s.: not significant, *p < 0.05, **p < 0.01, and ***p < 0.001.