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. 2019 Oct 29;10:4923. doi: 10.1038/s41467-019-12895-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Neural responses following vHP MCHR1 activation. a Color-coded overlays over a selection of representative coronal sections of the template brain show significant MCH-induced changes in regional cerebral glucose uptake (rCGU) as an indirect measurement of brain activation (Student’s t test, red/blue: increase/decrease in rCGU in the MCH group compared to the control group; n = 9 and 8, respectively). Numbers under images are approximate level along the anterior–posterior axis relative to the bregma (in mm). b Seed correlation analysis revealed statistically significant positive correlation between the seed in the ventral CA1 and ACB shell area in the MCH but not in the control group (Pearson’s correlation, orange/blue: positive/negative correlation with the seed). ACB nucleus accumbens, ACAd/ACAv anterior cingulate area, dorsal/ventral part, AId/AIv agranular insular area, dorsal/ventral part, AUD auditory area, TEa temporal association areas, BLA basolateral amygdalar nucleus, BMA basomedial amygdalar nucleus, CA1/CA3 CA1/CA3 area of the HP, COA cortical amygdalar nucleus, CP caudoputamen, DG dentate gyrus, DMH dorsomedial hypothalamic nucleus, ECT ectorhinal area, ENT entorhinal area, GU gustatory area, III oculomotor nucleus, IPN interpeduncular nucleus, LA lateral amygdalar nucleus, LD lateral dorsal nucleus thalamus, LGd lateral geniculate complex, dorsal part, LHA lateral hypothalamic area, MD mediodorsal nucleus thalamus, MEA medial amygdalar nucleus, PAGd periaqueductal gray, dorsal division, PIR piriform area, PL prelimbic area, PTLp parietal region, posterior association areas, RL rostral linear nucleus raphe, RR midbrain reticular nucleus, retrorubral area, RSPd retrosplenial area, dorsal part, SC superior colliculus, SSp primary somatosensory area, SSs supplemental somatosensory area, SUBv subiculum, ventral part, VIS visual areas, VM ventral medial nucleus thalamus, VPL ventral posterolateral nucleus thalamus, VTA ventral tegmental area, ZI zona incerta). Abbreviations are taken from ref. ³⁹