Table 2.

Population PK model parameters and confidence intervals

Parameter (unit)	Estimate	% RSE	95% CI bootstrap lower bound	95% CI bootstrap upper bound	Definitions RSE: root of standard error CI: confidence interval (obtained from bootstrap)
Structural model
$C{L}_{\mathit{pop}}$ (L/h)	0.195	5.69%	0.176	0.217	CL: clearance
$V{1}_{\mathit{pop}}$ (L)	2.30	7.45%	1.95	2.62	V1: central volume
$Q_{\mathit{pop}}$ (L/h)	0.078	21.3%	0.047	0.120	Q: inter-compartmental clearance
$V{2}_{\mathit{pop}}$ (L)	0.449	27.1%	0.279	0.776	V2: peripheral volume
Covariate effects
FFM effect on CL	0.701	12.0%	0.527	0.872	FFM: fat free mass
FFM effect on V1	0.726	13.0%	0.542	0.903
FFM effect on V2	0.842	72.7%	0.365	3.976
AGE effect on CL	− 0.302	19.1%	− 0.407	− 0.167
Between subject variability
CV of CL	0.456	9.22%	0.365	0.529	CV: coefficient of variation (defined as standard deviation of η)
CV of V1	0.542	11.3%	0.421	0.660
$Cor{r}_{CL-V1}$	0.797	7.50%	0.669	0.895	Corr: correlation between η
Residual variability
CV of proportional RUV	0.205	8.23%	0.169	0.232	RUV: residual unexplained variability