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. 2019 Oct 23;10:988. doi: 10.3389/fgene.2019.00988

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Copyright © 2019 Li, Hu, Wang, Deng, Yang, Hu, Li and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Network analysis of differentially expressed (DE) mRNAs in granulosa and theca layers. (A, B) Co-expression network of DE mRNAs from top 20 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of profiles 2 and 3 in the granulosa layer (A), as well as of profiles 5 and 7 in the theca layer (B). This interaction network includes 53 junctional adhesion-related genes (marked in yellow), 15 lipid metabolism-related genes (marked in red), and 13 genes that are involved in ovarian steroidogenesis (marked in blue) (A). Genes marked with triangles were down-regulated, and those marked with circles were up-regulated during follicle selection. Solid lines indicated direct interactions. Dark grey genes had interactions of activation or inhibition, while light grey lines had interactions without activation or inhibition. Activation →; Inhibition.