Table 4.
Association between age and endothelial activation marker levels in ARDS patients (mediation step 3)
| Coefficient [95% CI] | p value | Coefficient [95% CI]* | p value | Adjusted R2 | |
|---|---|---|---|---|---|
| Fractalkine | |||||
| Young adults | Reference | NA | Reference | NA | 0.193 |
| Middle-aged adults | − 0.26 [− 0.49, − 0.04] | 0.021 | − 0.17 [− 0.38, 0.03] | 0.103 | |
| Elderly | − 0.46 [− 0.69, − 0.23] | < 0.001 | − 0.26 [− 0.48, − 0.05] | 0.018 | |
| E-selectin | |||||
| Young adults | Reference | NA | Reference | NA | 0.048 |
| Middle-aged adults | − 0.31 [− 0.53, − 0.10] | 0.005 | − 0.27 [− 0.48, − 0.04] | 0.013 | |
| Elderly | − 0.24 [− 0.46, − 0.02] | 0.032 | − 0.21 [− 0.44, 0.02] | 0.064 | |
| P-selectin | |||||
| Young adults | Reference | NA | Reference | NA | 0.047 |
| Middle-aged adults | − 0.14 [− 0.36, 0.08] | 0.214 | − 0.09 [− 0.30, 0.13] | 0.510 | |
| Elderly | 0.03 [− 0.20, 0.25] | 0.818 | 0.05 [− 0.18, 0.27] | 0.661 | |
| ICAM-1 | |||||
| Young adults | Reference | NA | Reference | NA | 0.073 |
| Middle-aged adults | − 0.11 [− 0.26, 0.04] | 0.168 | − 0.05 [− 0.20, 0.10] | 0.547 | |
| Elderly | − 0.22 [− 0.37, − 0.07] | 0.005 | − 0.14 [− 0.29, 0.02] | 0.073 | |
| Ang2:Ang1 | |||||
| Young adults | Reference | NA | Reference | NA | 0.046 |
| Middle-aged adults | − 0.28 [− 0.73, 0.18] | 0.232 | − 0.29 [− 0.75, 0.15] | 0.208 | |
| Elderly | − 0.22 [− 0.68, 0.25] | 0.359 | − 0.19 [− 0.67, 0.28] | 0.441 | |
Data is presented as beta-coefficient (β) with a 95% confidence interval [CI]. All biomarkers are log-transformed. *Adjusted for ethnic background, gender, admission type, readmission, direct hit for ARDS, Charlson Comorbidity Index, APACHE-IV score adjusted for age, immunodeficiency, tidal volume per predicted body weight, and positive end-expiratory pressure. A p value < 0.05 was considered as statistically significant. ICAM-1 intracellular adhesion molecule-1, ANG-2:ANG1 angiopoetin-2:angiopoetin-1. Goodness of fit, adjusted R2. NA not applicable