Domain	Support for judgement	Judgement
Random sequence generation Was the allocation sequence adequately generated?		Low High Unclear
Allocation concealment Was allocation adequately concealed?		Low High Unclear
Blinding of participants and personnel Was knowledge of the allocated intervention adequately prevented during the study?		Low High Unclear
Blinding of outcome assessment Was knowledge of the allocated intervention adequately prevented during the study?		Low High Unclear
Incomplete outcome data Were incomplete outcome data adequately addressed? State whether attrition and exclusions were reported, the numbers in each intervention group (compared with total randomized participants), and reasons		Low High Unclear
Selective outcome reporting Are reports of the study free of suggestion of selective outcome reporting?		Low High Unclear
Other bias Role of possible conflicts of interest for study authors		Low High Unclear