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Raltegravir pharmacokinetic parameters from non-compartmental analysis [geometric mean (range)] for Cohort 1 initial doses
| Dose | Age at initial dose (hrs) | Cmax (mg/L) | AUC12 (mg*hr/L) | T ½ (hrs) | Tmax (hrs) | C24h (mg/L) | V2/F (L/kg) | Cl/F (L/kg/hr) |
|---|---|---|---|---|---|---|---|---|
| 3 mg/kg n=6 | 17.2 (9.9–25.4) | 3.36 (2.00–5.32 mg/L) | 29.5 (17.4–44.0 mg*h | 11.8 (7.9–15.7) | 6.5 (4.1–24.0) | 1.44 (0.662–3.65 mg/L) | 0.56 (0.35–0.80) | 0.033 (0.021–0.053) |
