Table 3.

Allometric scaling equations applied

Parameter	Abbreviation	Unit	Allometric Scaling
Volume of distribution (central compartment)	V2	L	V2 = θV2· (BW/25)1
Clearance	CL	L/hour	CL = CL(t) · (BW/25)0.75 $CL\left(t\right)={CL}_{base}+{CL}_{max}\left(1–e^{-{CL}_{tau}*Age}\right)$
Oral absorption rate constant	KA	1/hour	KA = KA(t) $KA\left(t\right)={KA}_{base}+{KA}_{max}\left(1–e^{-{KA}_{tau}*Age}\right)$
Volume of distribution (peripheral compartment)	V3	L	V3 = θV3· (BW/25)1
Inter-compartment clearance	Q	L/hour	CL = θQ·(BW/25)0.75

BW: Body weight in kg