Table 4.
Final model parameter estimates with 95% confidence intervals (CI-95%).
| Parameter | Unit | Value | CI-95% | Parameter | Value | CI-95% | ||
|---|---|---|---|---|---|---|---|---|
| V2 | L | 11.51 | 5.34 | 24.78 | Interindividual variability (IIV) | |||
| V3 | L | 26.47 | 15.75 | 44.47 | IIV-CLmax | 0.18 | 0.08 | 0.27 |
| CLmax | L/hour | 12.73 | 10.60 | 14.86 | IIV-Q | 0.61 | 0.13 | 1.10 |
| Q | L/hour | 1.22 | 0.76 | 1.97 | IIV-KAmax | 0.46 | 0.19 | 0.73 |
| KAmax | 1/hour | 0.76 | 0.32 | 1.20 | Residual unexplained variability (RUV) | |||
| F | - | 1 | RUV-prop | 0.56 | 0.49 | 0.62 | ||
| CLbase | L/hour | 0 | RUV-add | 4.44 | 0 | 82.21 | ||
| CLtau | 1/week | 0.20 | 0.07 | 0.34 | ||||
| KAbase | 1/hour | 0.08 | 0 | 2.66 | ||||
| KAtau | 1/week | 0.95 | 0 | 4.21 | ||||
RUV-prop: proportional RUV; RUV-add: additive RUV