Table 5.
Simulated dose regimen scenarios with exposure assessments. Exposure targets are Ctrough > 0.033 mg/L, Cmax < 8.72mg/L, AUC0–24 < 40 mg*hr/L and AUC0–12 < 20mg*hr/L. Green cells show that exposure target has been met, red cells denote violation of the exposure target at indicated day(s) and yellow cells denote that exposure is close to the target at the indicated day(s). Raltegravir doses indicated expressed in mg/kg.
| Regimen | Day 1–7 (wk-1) | Day 8–14 (wk-2) | Day 15–21 (wk-3) | Day 22–28 (wk-4) | Day 29–35 (wk-5) | Day 36–42 (wk-6) | Ctrough | Cmax | AUC0–24 (QD) | AUC0–12 (BID) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 QD | 3 BID | Day42 | Days 2+3 | ||||||
| 2 | 3 QD | 3 BID | 4 BID | Day42 | Days 2+3 | |||||
| 3 | 2 QD | 2 BID | 6 BID | Day28 | Days 2+3 | |||||
| 4 | 2 QD | 2 BID | 6 BID | Days 2+3 | Days 14–16 | |||||
| 5 | 3 QD | 3 BID | 6 BID | Day 14 | Days 2+3 | |||||
| 6 | 2 QD | 4 QD | 6 BID | Days 2+3 | Days 14–16 | |||||
| 7 | 2 QD | 3 BID | 6 BID | Days 2+3 | ||||||
| 8 | 2 QD | 6 QD | 6 BID | Day 28 | Days 2+3 | |||||
| 9 | 3 QD | 3 BID | 6 BID | Days 2+3 | ||||||
| 10 | 1.5 QD | 3 BID | 6 BID | |||||||
wk: week; QD: once daily; BID: twice daily; AUC0–24 assessed for days with QD dosing only; AUC0–12 assessed for days with BID dosing only