Table 5 Prognostic factors for vaginal cancer.
| Name | Standard factor | Risk/prognostic factor | Relevant for treatment |
|---|---|---|---|
| Tumor stage | Yes | Yes | Yes |
| Lymph node status | Yes | Yes | Yes |
| Size of respective lymph node metastasis | Yes | Unclear | Yes |
| Number of inguinal lymph nodes with metastatic disease | Yes | Unclear | Yes |
| Extracapsular extension of inguinal lymph node metastasis | Yes | Unclear | Yes |
| Perineural infiltration (PNI status) | Yes | Unclear | No |
| Lymph node infiltration (LN status) | Yes | Unclear | No |
| Venous invasion (V status) | Yes | Unclear | No |
| Resection margins (residual tumor status; R classification) | Yes | Yes | Yes |
| Depth of invasion in mm | Yes | Unclear | No |
| Grading | Yes | Unclear | No |
| Three-dimensional tumor size in cm | Yes | Unclear | Yes |
| Location of the cancer in the vagina | Yes | Unclear | Yes (poss. surgical approach) |
| Macroscopic type of growth of the carcinoma | Yes | Unclear | No |
| Multifocal carcinoma | Yes | Unclear | Yes (surgical approach) |
| Peritumoral VaIN | Yes | Unclear | Yes (surgical approach) |
| Histological tumor type | Yes | Unclear | No (pure adenocarcinoma, poss. not radiosensitive) |
| HPV confirmation in the carcinoma | No | Unclear | No |
| Pattern of invasion | No | Unclear | No |
| Immunohistochemical ultrastaging of lymph nodes for metastasis | No | Unclear | Unclear |
| Molecular markers | No | Unclear | Unclear |