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. 2019 Oct 29;9:15480. doi: 10.1038/s41598-019-52024-9

Table 1.

Binding affinities for ligands at primate AVPR1a.

AVPR1a K i 125I-OVTA Rank Order Potency
AVP Leu8-OXT Pro8-OXT Bmax (fmol/well) Kd (pM)
Human 0.63 ± 0.24 15.78 ± 0.33 8.71 ± 0.37 6.21 1165 AVP > Leu8 = Pro8
Macaque 1.21 ± 0.10 30.02 ± 0.16 23.77 ± 0.17 8.50 331 AVP > Leu8 = Pro8
Marmoset 0.86 ± 0.02 247 ± 0.06 175.9 ± 0.05 12.71 944 AVP > Leu8 = Pro8

IC50 presented as nM ± Std. Error. Efficacy is presented as % maximum AVP response ± Std. Error. Human (n = 3); Macaque (n = 3); Marmoset (n = 5). Leu8 = Leu8-OXT; Pro8 = Pro8-OXT.