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. 2019 Oct 29;9:15554. doi: 10.1038/s41598-019-52171-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Activation of whole-cell CFTR currents evoked by MSN in Caco-2 cells under a conventional whole-cell patch-clamp. (a–c) Representative responses of whole-cell currents to MSN (a) and effects of treatment with 10 μM CFTR inhibitor-172 (CFTR-inh: b) and pretreatment with 100 μM SQ22536 (SQ: c). Top panels: Time courses of MSN-evoked whole-cell currents recorded at +100 mV (filled circles) and −100 mV (open circles) under a ramp clamp. Grey bars show application of 400 μg/ml MSN. Filled bars show application of CFTR-inh and SQ. Bottom panels: Corresponding I-V relationships recorded at time points a–c in the top panels. (d) Peak current densities measured at +100 mV in response to MSN alone and together with CFTR-inh or SQ. Each column represents the mean ± S.E.M. (n = 5–17). ***P < 0.001 compared with MSN alone.