Online-only Table 1.
List of inhibitors.
| Abbreviation | Inhibitor | Primary target(s) (given by provider) | Term Accession Number | Term Source REF | PubChem CID | Formula | InChiKey | Provider |
|---|---|---|---|---|---|---|---|---|
| 5Z | (5Z)-7-oxozeaenol (LL-Z1640-2) | MAP3K7, MAP2K1 | CHEBI:67559 | CHEBI | 9863776 | C19H22O7 | NEQZWEXWOFPKOT-BYRRXHGESA-N | Enzo Diagnostics |
| 60 | BI605906 (BIX02514) | IKBKB | 23652660 | C17H22F2N4O3S2 | IYHHRZBKXXKDDY-UHFFFAOYSA-N | MRC | ||
| AK | Akt Inhibitor VIII (AKTi-1,2) | AKT1, AKT2, AKT3 | 135398501 | C34H29N7O | IWCQHVUQEFDRIW-UHFFFAOYSA-N | Merck Millipore | ||
| BI | Doramapimod (BIRB0796) | MAPK14, MAPK11 | CHEBI:40953 | CHEBI | 156422 | C31H37N5O3 | MVCOAUNKQVWQHZ-UHFFFAOYSA-N | Axon Medchem |
| CT | CHIR 99021 (CT99021) | GSK3A, GSK3B | CHEBI:91091 | CHEBI | 9956119 | C22H18Cl2N8 | AQGNHMOJWBZFQQ-UHFFFAOYSA-N | Sigma-Aldrich |
| D1 | BI-D1870 | RPS6KA1, RPS6KA3, RPS6KA2, RPS6KA6 | 25023738 | C19H23F2N5O2 | DTEKTGDVSARYDS-UHFFFAOYSA-N | Selleckchem | ||
| D4 | D4476 | CSNK1A1, TGFBR1 | CHEBI:91448 | CHEBI | 6419753 | C23H18N4O3 | DPDZHVCKYBCJHW-UHFFFAOYSA-N | Bio-Techne |
| F4 | 10058-F4 | MYC | 1271002 | C12H11NOS2 | SVXDHPADAXBMFB-JXMROGBWSA-N | Sigma-Aldrich | ||
| G2 | GSK2334470 | PDPK1 | CHEBI:91465 | CHEBI | 46215815 | C25H34N8O | QLPHOXTXAKOFMU-WBVHZDCISA-N | Sigma-Aldrich |
| G4 | GSK-429286 | ROCK1 | CHEBI:91332 | CHEBI | 11373846 | C21H16F4N4O2 | OLIIUAHHAZEXEX-UHFFFAOYSA-N | Sigma-Aldrich |
| JN | JNK-IN-8 (JNK Inhibitor XVI) | MAPK8, MAPK9, MAPK10 | 57340686 | C29H29N7O2 | GJFCSAPFHAXMSF-UXBLZVDNSA-N | Merck Millipore | ||
| P5 | PRT 062607 (P505-15) | SYK | 44462758 | C19H23N9O | TXGKRVFSSHPBAJ-JKSUJKDBSA-N | Axon Medchem | ||
| PD | PD0325901 | MAP2K1, MAP2K2 | CHEBI:88249 | CHEBI | 9826528 | C16H14F3IN2O4 | SUDAHWBOROXANE-SECBINFHSA-N | Sigma-Aldrich |
| PI | PI-103 | PIK3CA, PIK3CB, PIK3CD, PIK3CG, MTOR, PRKDC | CHEBI:90524 | CHEBI | 9884685 | C19H16N4O3 | TUVCWJQQGGETHL-UHFFFAOYSA-N | Selleckchem |
| PK | Toxoflavin (PKF118–310) | CTNNB1 | CHEBI:80729 | CHEBI | 66541 | C7H7N5O2 | SLGRAIAQIAUZAQ-UHFFFAOYSA-N | Sigma-Aldrich |
| RU | Ruxolitinib (INCB18424) | JAK1, JAK2 | CHEBI:66919 | CHEBI | 25126798 | C17H18N6 | HFNKQEVNSGCOJV-OAHLLOKOSA-N | Selleckchem |
| SB | SB-505124 | TGFBR1, ACVR1B, ACVR1C | 56924523 | C20H21N3O2 · xHCl · yH2O | DIDCCMVWCVRTNB-UHFFFAOYSA-N | Sigma-Aldrich | ||
| SF | SF1670 | PTEN | 9926586 | C19H17NO3 | VZQDDSYKVYARDW-UHFFFAOYSA-N | Sigma-Aldrich | ||
| ST | Stattic | STAT3 | CHEBI:86989 | CHEBI | 2779853 | C8H5NO4S | ZRRGOUHITGRLBA-UHFFFAOYSA-N | Sigma-Aldrich |
Drugs are annotated by PubChem CID, InChiKey and CHEBI ID. Further drug target by provider, provider and formula are recorded. An extended table recording target information for each inhibitor is also available in the figshare deposit25.