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. 2019 Oct 29;9:15458. doi: 10.1038/s41598-019-51865-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LXRβ and ABCA1 have different effects on feedback regulation of mevalonate pathway. (A) Relative gene expression analysis for mevalonate pathway genes HMGCR and HMGCS1 in crNT and crLXRb-1 TS600 glioma cells. Gene expression values were derived from quantitative real time PCR normalized to GAPDH and expressed as fold change dense/sparse for crNT and crLXRb-1. Error bars indicates SEM for at least 3 replicates. **p < 0.005, ****p = 0.00008 for multiple t-tests using procedure of Benjamini, Krieger and Yekutieli. (B) Relative gene expression analysis for mevalonate pathway genes HMGCR and HMGCS1 in crNT and crABCA1 TS600 glioma cells. Gene expression values were derived as in (A). Error bars indicates SEM for at least 3 replicates. **p < 0.005, ***p < 0.0005 for multiple t-tests using procedure of Benjamini, Krieger and Yekutieli.