Pergar 1987.
Methods | Double‐blind placebo‐controlled trial | |
Participants | 300 women with history of idiopathic fetal growth. Fetal growth retardation must be <10 percentile of Lubchenco et al. Therapy began at 15 to 17 weeks' gestation. Excluded: Presence of chronic disease, allergy to dipyridamole, uterine or malformation, secondary hypertension, early fetal death in a previous pregnancy, current use of anti inflammatory drugs or anticoagulants |
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Interventions | Exp: dipyridamole 225mg/day Control: placebo |
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Outcomes | Babies: birth weight related to GA | |
Notes | Conducted by doctors from 50 hospitals throughout France and Belgium. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Study appears to be randomised; however, French translation needed to confirm this |
Allocation concealment (selection bias) | Unclear risk | French translation needed to determine if allocation was concealed. |
Blinding (performance bias and detection bias) All outcomes | Low risk | Trial is double‐blind placebo‐controlled. |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | French translation needed to judge this. |
Selective reporting (reporting bias) | Unclear risk | French translation needed to judge this. |
Other bias | Unclear risk | No imbalance in baseline characteristics. French translation needed to determine if there may be any other sources of bias. |