Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Oct 29;9:15489. doi: 10.1038/s41598-019-51735-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Latency time of tumor development: (a) Kaplan-Meier curves showing the fraction of tumor-free animals as function of time after irradiation (or sham) for all animals that eventually developed a tumor (n = 84). The curves for the two control groups (AN and CBCT) were similar (p = 0.92; a, insert), but tumors developed significantly earlier after 3 × 8 Gy (VMAT: p = 0.0004, and AP/PA: p < 0.0001; Gehan-Breslow-Wilcoxon test; p < 0.05); (b) the median time to tumor (TTT) remained significantly reduced in the BHDV/HDV (p = 0.0005; Mann-Whitney U test) when the older age at treatment of the 3 × 8 Gy group (median 37.5 days) was considered; (c) no significant difference in the TTT for radiation-associated tumors (in LDV/BHDV/HDV) was observed between VMAT and AP/PA. Horizontal lines indicate median values. Abbreviations: TTT, time to tumor; AN, anesthesia only control group; CBCT, cone-beam computed tomography only control group; VMAT, volumetric-modulated arc therapy; AP/PA, anterior-posterior/posterior-anterior irradiation; Gy, Gray; NIRV, non-irradiated voume; LDV, low-dose volume; BHDV/HDV, bordering high-dose volume and high-dose volume combined.