Table 4.

Platelets do not influence the association between Factor2 PEAR1 methylation and WBC counts in the Moli-family cohort

	Model A				Model B
	Beta	SE	p value	R-square	Beta	SE	p value	R-square
WBC	− 0.123	0.058	0.036	0.020	− 0.150	0.054	0.006	0.025
Lymphocytes	0.210	0.055	0.0002	0.009	0.224	0.056	< 0.0001	0.051
Monocytes	0.239	0.055	< 0.0001	0.023	0.268	0.057	< 0.0001	0.069
Granulocytes	− 0.275	0.055	< 0.0001	0.046	− 0.286	0.056	< 0.0001	0.079

Model A adjusted by age, gender, BMI, smoking (being an ever smoker and pack-years), drinking (a drinker was defined as drinking daily more than 15 g of alcohol), being a proband for family recruitment, being a member of MI family as fixed effects, and family as a random effect. Model B is Model A +adjustment by platelets, PDW, platelet P-selectin, platelet/monocyte, and platelet/PMN. R-squares were calculated using a linear regression model including covariates used as fixed effect in the mixed models. Standardized values of phenotypes and methylation are reported. Significant p values are reported in italics