Table 4.

Non-parametric estimates of sensitivity, specificity, positive and negative likelihood ratios of prostate cancer detection in the third sampling, for increasing thresholds (from > 5 to > 10%) of GSTP1 methylation observed in the first and second negative biopsy; 97 cases and 109 controls with measured GSTP1 methylation in both the first and the second biopsy

Methylation threshold	n positive cases	n negative cases	n positive controls	n negative controls	Sens	Spec	LR+	LR−
	The highest methylation level between the first and second biopsy
> 5%	44	53	22	87	0.45	0.80	2.25	0.68
> 6%	32	65	12	97	0.33	0.89	3.00	0.75
> 7%	27	70	8	101	0.28	0.93	3.79	0.78
> 8%	19	78	4	105	0.20	0.96	5.34	0.83
> 9%	17	80	3	106	0.17	0.97	6.37	0.85
> 10%	14	83	2	107	0.14	0.98	7.87	0.87

Sens sensitivity, Spec specificity, LR likelihood ratio