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Schematic overview of the study design. Patients will undergo three titration procedures —subjective titration (green), titration PSG (orange) and, titration DISE (yellow) — in randomized order. This leads to six different possible sequences. A 1-week washout period is integrated between the different titration procedures. A follow-up sleep study is performed at the end of each titration method. DISE, drug-induced sleep endoscopy; MAD, mandibular advancement device; PSG, polysomnography
