Table 2.

Incidence rate of TB disease per 100 person-years in participants receiving first- and second-line ART

Characteristics	Overall		First-line ART		Second-line ART		p-value first- vs second-line ART
	IR	95%CI	IR	95%CI	IR	95%CI
Overall	3.94	3.48–4.46	4.39	3.86–5.00	1.64	1.01–2.63	< 0.001
Age
18–29	3.67	2.75–4.88	3.82	2.83–5.16	2.55	0.95–6.79	0.44
30–39	4.10	3.39–4.96	4.39	3.61–5.35	2.25	1.12–4.51	0.07
40–49	3.92	3.11–4.95	4.72	3.71–6.01	1.21	0.50–2.92	0.004
> 50	3.85	2.56–5.80	4.78	3.17–7.19	0	–	–
Sex
Female	3.26	2.69–3.95	3.46	2.84–4.22	1.67	0.75–3.72	0.08
Male	4.63	3.94–5.46	5.48	4.62–6.49	1.62	0.89–2.92	< 0.001
CD4+ count at respective ART initiation (cells/mm3)
> 350	1.14	0.61–2.12	1.94	0.97–3.89	0.42	0.10–1.71	0.06
S200–349	2.86	2.25–3.64	3.05	2.37–3.91	1.64	0.68–3.96	0.18
< 200	5.55	4.78–6.45	5.72	4.90–6.68	3.74	2.01–6.95	0.18
Time since respective ART initiation
< 3 months	112.77	92.23–137.89	122.22	99.85–149.60	13.63	1.92–96.82	0.02
3 to 6 months	17.23	11.97–24.79	17.49	11.81–25.88	15.78	5.92–42.04	0.84
> 6 months	2.05	1.72–2.44	2.22	1.84–2.67	1.19	0.67–2.10	0.04
Residence
Urban	4.31	3.74–4.96	4.63	4.00–5.36	2.37	1.43–3.93	0.01
Semi-urban or rural	3.01	2.31–3.94	3.74	2.85–4.91	0.50	0.12–2.00	0.006

ART Antiretroviral therapy, IR Incidence rate, CI Confidence interval