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. 2019 Oct 30;7:158. doi: 10.1186/s40478-019-0818-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Neuropathology of FXTAS. Luxol fast blue-H&E stain shows spongiosis of the cerebellar white matter (a). Abundant eosinophilic intranuclear inclusions (arrows) were found in neurons of the cerebral cortex, especially in hippocampal pyramidal cells (b). Intranuclear inclusions in the CA4 region of the hippocampus were immunorective for p62 (c), NTF1 (d) and CTF1 (e). Neurons and glia in pontine nuclei (f NTF1), as well as Bergmann glia and rare Purkinje neurons of the cerebellum also contained intranuclear inclusions (g NTF1). [Scale bar = 100 μm in a; 20 μm in b, c, d, e, f and g]