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. 2019 Oct 30;7:158. doi: 10.1186/s40478-019-0818-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — PSP-like changes were detected by AT8 immunohistochemistry as tufted astrocytes (a), globose tangles (b) and coiled bodies (c). (d) Heatmap of relative abundance of NTF1-positive pathology (upper row), AT-8 positive pathology (middle row) and p62-positive pathology (lower row). 0 = no pathology, 1 = mild pathology, 2 = moderate pathology and 3 = severe pathology). Scale bar: 20 μm