Table 1.

HLA-DRB1 four digit alleles with RA (Odds Ratio (OR)) and 95% Confidence Interval (CI))

HLA DRB1 allele	Cases (n=261)* Allele count (allele frequency)	Controls (n=362) Allele count (allele frequency)	RA Association Multivariable OR (95% Cl)	P value
0101	1 (0.0)	2 (0.0)
0102	26 (0.04)	30 (0.04)
0201	1 (0.0)	0 (0.0)
0301	28 (0.05)	63 (0.08)
0302	50 (0.09)	73 (0.10)
0401	63 (0.12)	24 (0.03)	4.0 (2.5–6.5)	<0.000 1
0402	1 (0.0)	0 (0.0)
0404	67 (0.13)	15 (0.02)	6.9 (3.9–12.2)	<0.000 1
0405	14 (0.02)	4 (0.01)	4.96 (1.6–15.2)	0.0018
0408	1 (0.0)	0 (0.0)
0410	3 (0.0)	2 (0.0)
0701	30 (0.06)	41 (0.06)
0804	13 (0.02)	30 (0.04)
0901	8 (0.02)	10 (0.01)
1001	27 (0.05)	21 (0.02)	1.8 (1.0–3.3)	0.039
1101	41 (0.08)	101 (0.14)	0.5 (0.4–0.8)	0.0008
1102	12 (0.02)	36 (0.05)
1114	2 (0.0)	1 (0.0)
1201	19 (0.04)	28 (0.04)
1202	1 (0.0)	4 (0.0)
1301	40 (0.08)	92 (0.13)	0.6 (0.4–0.8)	0.004
1302	21 (0.04)	47 (0.06)	0.6 (0.4–1.0)	0.06
1303	6 (0.01)	14 (0.02)
1336	0 (0.0)	1 (0.0)
1340	0 (0.0)	1 (0.0)
1401	2 (0)	8 (0.01)
1404	1 (0.0)	0 (0.0)
1417	2 (0.0)	0 (0.0)
1501	10 (0.02)	14 (0.02)
1503	32 (0.06)	61 (0.08)
1506	0 (0.0)	1 (0.0)
Total	522	724

^*5 cases were not typed successfully