Table 3.
The univariate association of HLA-DR1 haplotypes constructed from amino acid at positions 11, 71 and 74.
| Haplotype | Haplotype frequencies | Haplotype associations OR (95%CI) | |
|---|---|---|---|
| Case | Control | ||
| V_K_A | 0.12 | 0.02 | 4.52 (2.68–7.61)** |
| V_R_A | 0.22 | 0.06 | 4.44 (3.01–6.56)** |
| D_R_E | 0.02 | 0.01 | 1.44 (0.53–3.94) |
| L_R_A | 0.05 | 0.05 | 1.08 (0.62–1.87) |
| G_R_Q | 0.05 | 0.06 | 0.99 (0.59–1.66) |
| S_K_R | 0.15 | 0.18 | 0.83 (0.61–1.15) |
| P_A_A | 0.08 | 0.1 | 0.77 (0.51–1.16) |
| S_R_A | 0.13 | 0.20 | 0.59 (0.43–0.82)** |
| S_K_A | 0.01 | 0.02 | 0.55 (0.19–1.57) |
| S_E_A | 0.14 | 0.24 | 0.52 (0.38–0.71)** |
| S_R_L | 0.02 | 0.04 | 0.47 (0.22–0.98)* |
| S_R_E | 0.004 | 0.01 | 0.36 (0.07–1.73) |
V=Valine, S=Serine, A=Alanine, R=Arginine, E=Glutamic acid, K=Lysine, D=Aspartic acid
*
p<0.004 (Bonferroni adjusted for 12 tested)