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. 2019 Oct 29;14:337. doi: 10.1186/s13018-019-1391-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Quantitative real-time PCR analysis was performed for relative mRNA expression of genes that were involved in the cartilage catabolism in control and case study. Quantitative analysis suggested that expression of ASPN and COMP genes upregulated in case group compared to their respective control. β-Actin served as housekeeping gene for normalization. Values are expressed as mean ± SEM (n = 24). *p < 0.05 vs control