Table 2.

Genotype association between SNPs in ASPN gene and knee osteoarthritis

	Genotype	All subjects			Women			Men
		Control (%)	Case (%)	OR (95% CI), p value	Control (%), 276	Case (%), 295	OR (95% CI), p value	Control (%), 224	Case (%), 205	OR (95% CI), p value
Genotype	3739606
	GG	261 (52.2)	238 (47.6)	1.00 (ref)	139 (50.36)	139 (47.79)	1.00 (ref)	122 (54.46)	99 (48.29)	1.00 (ref)
	GT	209 (41.8)	217 (43.4)	1.13 (0.87–1.47), 0.325	119 (43.11)	129 (43.72)	1.06 (0.75–1.50), 0.703	90 (40.17)	88 (42.92)	1.20 (0.81–1.79), 0.355
	TT	30 (6.0)	45 (09.0)	1.64 (1.00–2.69), 0.046*	18 (6.52)	27 (8.47)	1.36 (0.71–2.62), 0.341	12 (5.35)	18 (8.78)	1.84 (0.85–4.02), 0.117
Allele	G	731 (73.1)	693 (69.3)	1.00 (ref)	397 (71.92)	411 (69.66)	1.00 (ref)	334 (74.53)	286 (69.75)	1.00 (ref)
	T	269 (26.9)	307 (30.7)	1.20 (0.99–1.46), 0.060	155 (28.07)	179 (30.33)	1.11 (0.86–1.44), 0.401	114 (25.44)	124 (30.24)	1.27 (0.94–1.71), 0.116
Genotype	Rs 331377
	AA	201 (40.2)	183 (36.6)	1.00 (ref)	114 (41.30)	111 (37.62)	1.00 (ref)	87 (38.83)	72 (35.12)	1.00 (ref)
	AG	154 (30.8)	166 (33.2)	1.18,(0.88–1.59), 0.264	86 (31.15)	96 (32.54)	1.14 (0.77–1.69), 0.493	68 (30.35)	70 (34.14)	1.24 (0.78–1.96), 0.349
	GG	145 (29.0)	151 (30.2)	1.14 (0.84–1.54), 0.385	76 (27.53)	88 (29.83)	1.18 (0.80–1.78), 0.368	69 (30.80)	63 (30.73)	1.10 (0.69–1.75), 0.677
Allele	A	556 (55.6)	532 (53.2)	1.00 (ref)	314 (56.88)	318 (53.89)	1.00 (ref)	242 (54.01)	214 (52.19)	1.00 (ref)
	G	444 (44.4)	468 (46.8)	1.10 (0.92–1.31), 0.281	238 (43.11)	272 (46.10)	1.12 (0.89–1.42), 0.310	206 (45.98)	196 (47.80)	1.07 (0.82–1.40), 0.593

OR odds ratio, 95% CI 95% confidence interval, ref reference category

*p < 0.05 is considered statistically significant