Table 3.
Genotype association between SNP in COMP (HpyCH4IV_rs34467947) gene and knee osteoarthritis (KOA)
| All subjects | Women | Men | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Control (%) | Case (%) | OR (95% CI), p value | Control (%), 276 | Case (%), 295 | OR (95% CI), p value | Control (%), 224 | Case (%), 205 | OR (95% CI), p value | ||
| Genotype | HpyCH4IV-rs34467947 | |||||||||
| CC | 467 (93.4) | 458 (91.6) | 1.00 (ref) | 259 (93.84) | 272 (92.20) | 1.00 (ref) | 208 (92.85) | 186 (90.73) | 1.00 (ref) | |
| CT | 29 (5.8) | 35 (7.0) | 1.23 (0.74–2.04), 0.423 | 14 (5.07) | 18 (6.10) | 1.22 (0.59–2.51), 0.580 | 15 (6.69) | 17 (8.29) | 1.26 (0.61–2.60), 0.519 | |
| TT | 4 (0.8) | 7 (1.4) | 1.78 (0.51–6.13), 0.351 | 3 (1.08) | 5 (1.69) | 1.58 (0.37–6.70), 0.526 | 1 (0.04) | 2 (0.9) | 2.23 (0.20–24.86), 0.501 | |
| Allele | C | 963 (96.3) | 951 (95.1) | 1.00 (ref) | 532 (96.37) | 562 (95.25) | 1.00 (ref) | 431 (96.20) | 389 (94.87) | 1.00 (ref) |
| T | 37 (3.7) | 49 (4.9) | 1.34 (0.86–2.07), 0.185 | 20 (3.62) | 28 (4.74) | 1.32 (0.73–2.38), 0.344 | 17 (3.79) | 21 (5.12) | 1.36 (0.71–2.63), 0.345 | |
OR odds ratio, 95% CI 95% confidence interval, ref reference category