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. 2019 Oct 25;12:8821–8832. doi: 10.2147/OTT.S221161

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© 2019 Wang et al.

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GDNB inhibits tumor formation in vivo through the ERK pathway. Lung tumor-bearing mice were randomly divided into 4 groups (ten in each group): Control group (0.9% saline) and Administration groups (10, 20, 30 mg/kg GDNB). (A) Tumor weight. (B) Tumor image. (C) The protein levels of Ras, c-Myc, MEK1/2, p-MEK1/2, ERK1/2 and p-ERK1/2 were measured by Western blotting. (D) The number of apoptotic tumor cells was detected by TUNEL assay. (E) The expression of caspase 3, ki67 and vimentin in tumor tissues was measured by IHC. (*p < 0.05, **p <0.01 vs control group).