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. 2019 Oct 18;15(10):e1007390. doi: 10.1371/journal.pcbi.1007390

Fig 5. Effect of Val66Met on contacts between blobs.

Fig 5

a) Blob-blob contact probability for the V66 self-avoiding heteropolymer (SAHP) from Monte Carlo simulations (further described in Methods). The black boxes mark the regions identified. b) Blob-blob contact probability shown in panel a for the V66 (left) and M66 (right) sequences of the real protein (RP). The x and y axes are annotated with cartoon representation of the prodomain; circles are drawn to the scale of each blob’s size. c) Population of contacts in SAHP, RP (top) and enrichment in RP contacts with respect to SAHP contacts (bottom) for each region pair. The errors represent standard errors (n = 1088 as described in Methods). d) Difference (M66-V66) between the contact probabilities shown in panel b. e) Differences shown in panel d with respect to SAHP; interactions more frequently found in M66 or V66 sequence are in blue and orange respectively.