Table 1.

Summary Statistics for the De novo Reference Genomes of the 2 Patients

	Patient 1	Patient 2
Total bases	5 172 759	5 275 491
Mean depth of coverage	25.3X	74.1X
Number of contigs	28	46

References were assembled for the first temporal sample from each patient (patient_1_S1 and patient_2_S1; see Methods).