Table 1.
Clinical details of multiple sclerosis and control cases
| Case | Age/gender | Genotype a | Diagnosis | Duration, years | PM delay, h:min | Cause of death |
|---|---|---|---|---|---|---|
| 1 | 69/F | PPMS/SPMS | 53 | 7:30 | Respiratory failure with heart failure | |
| 2 | 70/F | PPMS/SPMS | 40 | 6:55 | Urine tract infection | |
| 3 | 50/M | PPMS/SPMS | 15 | 5:25 | Pneumonia | |
| 4 | 66/F | SPMS | 11 | 6:00 | Pneumonia | |
| 5 | 75/F | PPMS/SPMS | 24 | 5:00 | Heart failure | |
| 6 | 49/M | SPMS | 25 | 8:00 | Pneumonia | |
| 7 | 66/M | SPMS | 26 | 7:30 | Ileus | |
| 8 | 64/F | Low | SPMS | 31 | 10:10 | Urinary tract infection |
| 9 | 61/M | High | SPMS | 18 | 9:15 | Euthanasia |
| 10 | 77/F | PPMS | 24 | 10:00 | Euthanasia | |
| 11 | 67/F | Mixed | SPMS | 25 | 9:15 | Palliative sedation |
| 12 | 45/M | PPMS | 10 | 7:45 | Pulmonary embolism, cardiac arrest | |
| 13 | 59/F | SPMS | 24 | 4:45 | Euthanasia | |
| 14 | 58/F | SPMS | 36 | 10:40 | Euthanasia | |
| 15 | 44/M | PPMS | 21 | 10:15 | End stage of MS | |
| 16 | 51/M | SPMS | 19 | 11:00 | Unknown | |
| 17 | 57/F | Low | RRMS | 26 | 8:40 | Urosepsis |
| 18 | 57/F | High | PPMS | 29 | 11:00 | Euthanasia |
| 19 | 73/M | Mixed | RRMS | 26 | 8:00 | Urosepsis by advanced MS |
| 20 | 76/F | High | SPMS | 25 | 7:55 | Euthanasia |
| 21 | 56/M | Mixed | PPMS | 14 | 9:50 | Cachexia |
| 22 | 74/M | Mixed | PPMS | 15 | 10:15 | Cardio-respiratory insufficiency |
| 23 | 60/F | Mixed | SPMS | 7 | 10:40 | Euthanasia |
| 24 | 54/M | Low | PPMS | 12 | 8:15 | Euthanasia |
| 25 | 75/M | Mixed | PPMS | 46 | 10:10 | Pneumonia |
| 26 | 50/F | Mixed | SPMS | 17 | 7:35 | Euthanasia |
| 27 | 53/M | SPMS | 24 | 10:00 | Euthanasia | |
| 28 | 66/F | PPMS | 13 | 9:35 | Euthanasia | |
| 29 | 56/M | Mixed | SPMS | 14 | 10:10 | Suicide |
| 30 | 66/F | SPMS | 16 | 10:45 | Pulmonary hypertension | |
| 31 | 81/F | SPMS | 31 | 4:35 | Pneumonia | |
| 32 | 63/M | SPMS | 25 | 8:15 | Pneumonia, cachexia, dehydration | |
| 33 | 75/F | High | SPMS | Unknown | 9:45 | Fall, subdural haematoma |
| 34 | 61/F | High | Unknown | Unknown | 10:00 | Euthanasia |
| 35 | 50/M | Low | SPMS | 21 | 10:50 | Unknown |
| 36 | 49/F | Unknown | Unknown | 8:30 | Unknown | |
| 37 | 50/F | SPMS | 18 | 9:05 | Euthanasia | |
| 38 | 57/M | PPMS | 24 | 10:15 | Sepsis | |
| 39 | 35/F | SPMS | 10 | 10:20 | Euthanasia | |
| 40 | 54/F | Unknown | 27 | 9:25 | Respiratory failure | |
| 41 | 67/M | SPMS | 38 | 11:00 | Sudden death | |
| 42 | 54/M | SPMS | 29 | 6:40 | Euthanasia | |
| Biopsy | ||||||
| 1 | 51/M | Demyelinating disease, suspected MS | ||||
| 2 | Unknown/unknown | Demyelinating disease, suspected MS | ||||
| 3 | 27/M | Demyelinating disease, suspected MS | ||||
| 4 | 31/F | Demyelinating disease, suspected MS | ||||
| Controls | ||||||
| 1 | 61/F | Control | N/A | 6:50 | Euthanasia | |
| 2 | 73/F | Control | N/A | 4:00 | Lung fibrosis and renal insufficiency | |
| 3 | 67/M | Control | N/A | 4:30 | Cardiac shock, organ failure | |
| 4 | 81/M | Control | N/A | 5:30 | Prostate carcinoma | |
| 5 | 67/M | Control | N/A | 18:35 | Myocardial infarction | |
| 6 | 84/F | Control | N/A | 4:45 | Respiratory failure | |
| 7 | 91/F | Control | N/A | 7:45 | Decompensatio cordis | |
| 8 | 56/M | Mixed | Control | N/A | 14:00 | Heart failure |
| 9 | 92/F | Control | N/A | 7:00 | Acute death | |
| 10 | 62/M | Mixed | Control | N/A | 7:20 | Unknown |
| 11 | 49/M | Mixed | Control | N/A | 6:15 | Euthanasia, Hodgkin’s lymphoma |
| 12 | 51/M | Control | N/A | 7:30 | Euthanasia | |
a
Cases selected for autoradiography.
F = female; M = male; MS = multiple sclerosis; N/A = not applicable; PM = post-mortem; PP = primary progressive; RR = relapsing remitting; SP = secondary progressive.