Figure 2.
Genome-wide polygenic risk for generalized epilepsy or focal epilepsy in the exploration and replication cohorts. Shown are the means of the standardized GE-, FE-, and type 2 diabetes-PRS with 95% confidence intervals for the European-ancestry population controls (highlighted in blue; n = 20 435), the European-ancestry generalized epilepsy and focal epilepsy Epi25 exploration cohorts (highlighted in green; GE-Epi25-EUR, n = 2256; FE-Epi25-EUR, n = 3449), and the European-ancestry generalized epilepsy and focal epilepsy Cleveland Clinic replication cohorts (highlighted in red; GE-Cleveland-EUR, n = 85; FE-Cleveland-EUR, n = 535). The P-values for the differences between cases and population controls are given as numbers. The threshold for statistical significance after Bonferroni correction was set to α = 1.67 × 10−2 (three tests per cohort).