Figure 4.

Gene ontology (GO) analyses were performed using the Database for Annotation, Visualization, and Integrated Discovery tool to assess biological processes that are represented in the Pol II-UP and Pol II-DOWN genes in SynT vs CytT. (a) Functional annotation of biological processes showed that Pol II-UP genes are enriched in functions involved in hypoxia, angiogenesis, and placental development. (b) By contrast, Pol II-DOWN gene functions included cellular adhesion and negative regulation of apoptosis.