Figure 7.

(a) Genome browser view of ChIP-seq analysis of interferon-inducible gene IFIT family members on human chromosome 10 indicates that increased binding of Pol II to the gene promoters in SynT vs CytT is correlated with increased active histone marks. (b) These changes in binding of endogenous Pol II and histone H3 modifications indicative of active chromatin are correlated with upregulated expression of the IFIT2 and IFIT3 genes in SynT (18 h of culture) vs CytT (0 h) analyzed by RT-qPCR. Data are the mean ± SEM of triplicate samples. Significantly different from 0 h (***P < 0.001).