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. 2019 Jul 11;160(9):2189–2203. doi: 10.1210/en.2019-00144

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Figure 9. — Decreased binding of Pol II and of the active histone marks H3K9Ac and H3K27Ac to the promoters and enhancers of the NR4A1 (NUR77), NR4A2 (NURR1), and NR4A3 (NOR1) genes is correlated with downregulation of their expression during SynT differentiation, whereas binding of H3K4me3 and H4K27me3 remain unchanged. (a) Genome browser views of binding of Pol II and of active and repressive histone marks to the promoters/enhancers of the NR4A1, NR4A2, and NR4A3 genes. (b) RT-qPCR of RNA isolated from midgestation placenta before and after 18 h of culture revealed marked downregulation of all three genes during SynT differentiation. Data are the mean ± SEM of triplicate samples. Significantly different from 0 h (***P < 0.001; ****P < 0.0001).