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. 2019 Aug 28;3(11):2107–2113. doi: 10.1210/js.2019-00241

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Copyright © 2019 Endocrine Society

This article has been published under the terms of the Creative Commons Attribution Non-Commercial, No-Derivatives License (CC BY-NC-ND; https://creativecommons.org/licenses/by-nc-nd/4.0/).

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Figure 2. — Immunohistochemical characterization of steroid hormone nuclear receptor COUP-TFII expression on the ovotestis gonad from 46,XX subject carrying a 3-Mb 15q26.2 heterozygous deletion. (A) Low-power scanning field showing left to right ovotesticular dysgenetic gonad containing testicular seminiferous tubules (st), merged rete testis/rete ovarii (rt/ro), and ovarian follicular epithelium (fe) with hematoxylin and eosin (H&E) staining. (B) Dysgenetic ovarian follicular epithelium showing granulosa (*) and theca (**) cell layers, surrounded by ovarian stroma (***) on H&E (200×). (C) Granulosa cells lining in a theca lutein cyst where no primary oocytes were found (H&E). (D) Seminiferous tubules are devoid from germinative cells and contain only Sertoli cells surrounded by some luteinized stromal cells (H&E). Weak nuclear immunostaining for COUP-TFII immunoperoxidase in granulosa (E) and Sertoli (F) cells fulfilling seminiferous tubules of ovotesticular tissue in comparison with ovary (from young woman/ 200×) and testis (elderly man / 400×) external control tissues used in the same immunostaining bath, which are zoomed in the upper-right-hand corner of E and F.