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. 2019 Jul 30;47(19):e114. doi: 10.1093/nar/gkz659

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Evaluation of function and toxicity of photo-cleavable molecules T0, T1 and T2. (A) Transduction capability of lentiviral vectors with T0, T1 and T2 conjugated at residue Y116. The lentiviral vector was packaged with the luciferase reporter gene. Viral transduction capability was measured by relative luciferase activity. ‘-’ indicates no conjugation as negative control. (B) Transduction ability of lentiviral vectors with T0, T1 and T2 conjugated at residue Y77. (C) Photo-switchable gene delivery by lentiviral vector conjugated with T0, T1 and T2 at residue Y77 (Y77-T0, Y77-T1 and Y77-T2, respectively). (D) Cytotoxicity of T0, T1 and T2, at various concentrations of the photo-cleavable linker, with or without UV irradiation. **P < 0.01, *P < 0.05 versus corresponding control, n = 3.